Current Projects

Biological networks in stored red cells from G6PD-deficient donors, 2021-2022

• Storability and Post-transfusion Performance of Erythrocytes from beta-Thalassemia minor Donors, 2018-2022, Supported by the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Innovation (GSRI), Grant agreement No. 2032

• Supplementation of RBC storage solutions with antioxidants, 2020-2022, Operational Program “Human Resources Development, Education and Lifelong Learning”, Reinforcement of Postdoctoral Researchers - 2nd Cycle” (MIS-5033021), State Scholarships Foundation (ΙΚΥ)

• Thalassemia and Transfusion: a Tango for Two (THALATTA 4/2), 2019-

 

Previous Projects

• Congenital dyserythropoietic anemias, 1996-2001
• RBC membrane disorders, 1996-1999 (General Secretariat for Research and Innovation, GSRI, YPER program)
• RBC proteins in inherited and acquired diseases, 1999-2001 (PENED program)
• RBC storage lesion in CPDA preservative solution, 2005
• RBC membrane proteins in diabetic retinopathy, 2005-2008
• RBC-derived extracellular vesicles during storage, 2006-2008
• RBC aging during storage in CPD-SAGM preservative solution , 2008-2010
• Characterization of microvesicles in units of Fresh Frozen Plasma, 2011-2015 (Hellenic Society of Blood Transfusion)
• Follow-up study of RBC biology in End Stage Renal Disease, 2009-2014
Apolipoprotein J/Clusterin in RBCs, 2009-2011
• Effect of pre-storage leukoreduction on RBC storage lesion with emphasis to the accumulation of extracellular vesicles, 2010-2020

Donor variation effects on RBC storage lesion, 2013-
a) Serum uric acid levels, 2013-2017
b) G6PD deficiency, 2014-2022
c) Red cell osmotic fragility, 2016-2022
d) Sex, 2018-2020
e) beta-thalassemia traits, 2015-2022

Recipient variation effects on the performance of transfused RBCs:
a) Uremic plasma, 2016-2018
b) Plasma from G6PD-deficient subjects
c) Plasma from beta-thalassemia major patients

RBC proteasomes: regulation, topology, activity, 2020-
• RBC characteristics in ESRD patients resistant to erythropoietin therapy, 2015-2017
Hemodiafiltration versus conventional hemodialysis on RBC performance, 2015-2017
• Study of Fresh Frozen Plasma from G6PD-deficient donors, 2015-2017
• Coagulation abnormalities in renal pathology, 2018-2020
• Post-storage performance of RBCs from beta-thalassemia trait donors (mouse model), 2019-2020
Free vs. vesicular Hb in units of stored RBCs, 2012-2021